MORPHOFUNCTIONAL STATE OF THE MESENTERIC LYMPH NODES UNDER THE INFLUENCE OF GOLD NANOPARTICLES IN THE EXPERIMENT

Zlobina Olga Vyacheslavovna, Assistant, sub-department of histology, Saratov State Medical University named after V .I. Razumovsky , zlobinaow@rambler.ru
Bugaeva Irina Olegovna, Doctor of medical sciences, professor, head of sub-department of histology, Saratov State Medical University named after V. I. Razumovsky, bugaeva@sgmu.ru
Pakhomiy Svetlana Sergeevna, Assistant, sub-department of pathologic anatomy, Saratov State Medical University named after V. I. Razumovsky, s-firsova03@rambler.ru
Bucharskaya Alla Borisovna, Candidate of biological sciences, director of the Research and educational center of fundamental medicine and nano-technologies, Saratov State Medical University named after V. I. Razumovsky, allaalla_72@mail.ru
Maslyakova Galina Nikiforovna, Doctor of medical sciences, professor, head of sub-department of pathologic anatomy, Saratov State Medical University named after V. I. Razumovsky, gmaslyakova@yandex.ru

576.6:576.33:615.017:616.079:615.2/.3.001.37:616-091.8

The authors have studied the morphofunctional state of the mesenteric lymph nodes of white rats under the influence of gold nanoparticles in the experiment. After oral introduction of gold nanoparticles with a diameter of 1–3, 15 and 50 nm the morphometric analysis of cell populations in the structural-functional areas of lymph nodes showed quantitative changes in the ratio of lymphocyte populations with different degrees of maturity.The revealed changes presuppose activation of the migration, proliferation and differentiation of immune cells under the influence of gold nanoparticles.

gold nanoparticles, mesenterial lymphatic nodes, cell populations.